Top Once Human Builds for PvE & PvP

In Once Human, your combat effectiveness hinges on strategic gear and weapon selection. Whether facing corrupted creatures in PvE or attacking rival bases in PvP, a optimized loadout determines whether you emerge victorious or face defeat.

This guide highlights four top-tier builds currently dominating Once Human, complete with weapon recommendations, gear modifications, synergy breakdowns, and tactical advice. From area-of-effect specialists to critical hit machines, every build showcased works exceptionally well for both solo adventurers and team players.

New to the wasteland? Our Once Human beginner's guide provides the perfect starting point!

Pro Tips for Maximizing Your Loadout

Synergize weapon traits and modifications: Equip gear that amplifies your weapon's elemental properties or special effects. Continuous improvement matters: Higher rarity and upgrade levels provide substantial power spikes—never settle for outdated equipment. Prepare alternative configurations: Maintaining situational loadouts lets you counter specific mutant types or PvP strategies.

Every Once Human build shines in particular situations—be it battling bosses, clearing hordes, or eliminating players swiftly. Test different combinations, optimize your modifications, and switch tactics based on mission objectives or enemy vulnerabilities.

For peak performance—flawless combat responsiveness, efficient resource farming, and streamlined inventory handling—experience Once Human through BlueStacks. Enjoy buttery-smooth frame rates and customizable controls for superior gameplay.